Ric,
The “Big E” is the local name for the “Eastern States Exposition” - a very large fairground complex in West Springfield, MA. The Big E hosts everything from horse and cattle shows, machinery expos, stamp collecting shows, gun and knife shows, you name it. The local model railroad club - the Amherst Railway Society - hosts a big show there either the last weekend of January or the first weekend of February. I’ve been going for the last 20 years. The show is now up to four large buildings and close to 200,000 visitors - it will take close to two hours just to walk through once.
In addition to local hobby shops, most manufacturers, publishers, kit suppliers, etc., attend. There are also numerous sectional layouts (last year they a huge O scale loop - the UP Big Boy hauling a train of over 100 PFE reefers was to die for!). They hold seminars, demonstrations, etc. Though not specifically targeted at large scale, it is still worth attending.
See: http://www.railroadhobbyshow.com/
It’s probably not as big as Timomium, but it’s the largest show in New England.
Brian