On another forum (concerns itself with layout design ;)) a member is contemplating an N-scale layout with a Southern Mountain theme. The space is a given (restricted), the druthers are: double track main to keep the trains a-rolling. mining operations industries engine service facility and here is what I would do with those parameters. In N-scale there is a 5.5" height difference between lowest and highest.
Given the track arrangement and the popularity of running them in circles this has possibilities in LS, too. More on that later.